
Incidence of hepatitis C may be decreasing considering the decrease in the seroprevalence in the population younger than 40 related to the previous serosurvey. It is increasing in older age groups as the population at risk ages. Seroprevalence of HCV antibodies in the Community of Madrid is similar to that shown in other regions of Spain. Statistically significant associations were found for age, education, history of hepatitis C and consultation regarding liver problems. In comparison with the 1999 survey, prevalence fell for the age groups 21–30 and 31–40 years and increased for the age group 41–60. The age group with the highest prevalence was 41–60 years. Prevalence of HCV antibodies for the age group 16–80 years was 1.8% (95% CI: 1.3–2.5). Seroprevalence of HCV antibodies, prevalence ratios by age groups in comparison with 1999 survey data and prevalence association with risk factors were assessed using a logistic regression model. The sampling frame consisted of public blood extraction centers attached to the Madrid Health Service. Two-stage cluster sampling was performed, with stratification by socioeconomic status and percentage immigrant population. Descriptive cross-sectional study of a target population consisting of Community of Madrid residents aged 16–80 years old.

The aim of this study was to estimate the prevalence of HCV antibodies in the Community of Madrid, assess changes in recent years and analyse associated risk factors.
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